Laser analytical techniques provide some conveniences for the study of archaeological artefacts and works of art. These are simplicity, directness and fastness as well as possibility of infield studies. Laser-induced fluorescence spectroscopy can be applied for molecule composition analysis of a given object’s surface. The resulting information helps to identify an organic and inorganic compounds, organic impurities, etc. The reported method is successfully applied for authentication of studied subjects and for direct monitoring and assessment of the effects of conservation-restoration procedures. In the „Metal Vapour Lasers“ laboratory at the Institute of Solid State Physics, BAS, various laser applications are being developed for preservation of cultural heritage, including laser-induced fluorescence. The aim of our current research is to study a wide range of materials (pigments, dyes, adhesives and binders), commonly found in objects of historical value. This will create a comprehensive database that will allow further investigation of real artefacts and monuments.